Two questions are typically asked:
First, do colleges give extra weight to grades earned in honors or Advanced Placement (AP) courses? The answer is usually – either by formally recalculating the student’s grade-point average, or by informally “inflating” the grades earned the more advanced classes.
Second, is it better to earn a “B” in an Honors or AP class; or an “A” in a regular class? Most admissions people answer the question with the half-cynical remark, “It is better to get an “A” in the AP course.” That doesn’t directly answer the question, but it does give a peek inside the system.
Recommendation: Get the “A” in the toughest course you can.